Resources and Research

Mushroom Nutrition Resources & Research

The Mushroom Council has spent more than a decade investing in scientific research to better understand the nutritional benefits of mushrooms. The following are fact sheets that address some of today’s most relevant nutrition topics from weight management to sustainability. For full studies, view the Research section at the bottom of the page.

Fact Sheets

General Nutrition

Mushroom Nutrition At-A-Glance

A fact sheet that gives an overview of mushrooms’ nutritional benefits. [download the PDF]

Mushroom: A Food for a Better Mood

Mushrooms are an excellent source of niacin, a nutrient shown to improve mood disorders.[download the PDF]

Mushrooms: The Perfect Partner in a Gluten-Free Diet Fact Sheet

Understanding what is gluten-free and what isn’t can also take research and time. Simply said, like all fruits and vegetables, mushrooms are naturally gluten-free, and make a delicious and nutritious addition to a gluten-free diet.  [download the PDF]

Feed Your Immune System

Taking a closer look at nutrients found in mushrooms.  [download the PDF]

Mushroom Nutrition Facts Panels

Nutritional facts panels for white, crimini, portabella, enoki, oyster and shiitake mushrooms. [download the PDF]

Mushroom Varieties Chart

A guide to common mushroom varieties, their attributes and nutritional values. [download the PDF]

Feed Your Immune System Handbook

Includes mushroom information with an emphasis on immune-supporting nutrients, recipes and more.   [download the PDF]

Vitamin D

Vitamin D Fact Sheet

A fact sheet about mushrooms and vitamin D, including the health impact and risks associated with vitamin D deficiency. [download the PDF]

The Blend™

The Better-For-You-Blend Fact Sheet

With The Blend™, it’s never been easier to enjoy healthier versions of your favorite recipes without sacrificing taste and texture. [download the PDF]

Flavor-Enhancing Properties of Mushrooms Fact Sheet

A study from the Culinary Institute of America and University of California-Davis, published in the Journal of Food Science, found that blending finely chopped mushrooms with ground meat enhances flavor and nutrition. [download the PDF]

Sodium

Cut the Sodium with Mushrooms – Less Salt. More Flavor

A 2014 study from the Culinary Institute of America and University of California-Davis study found you can maintain flavor while reducing sodium intake with mushrooms.
[download the PDF]

Sustainability

Healthy on the Plate, Gentle on the Planet

The Mushroom Sustainability Story: The lines between health and sustainability are beginning to blur – a healthy diet should include food choices that respect future accessibility to nutritious food and overall global health. [download the PDF]

Weight Management

Manage Your Weight with Mushrooms

A fact sheet about how eating mushrooms can help manage weight and contribute to overall health and wellness.
[download the PDF]

How Mushrooms Fit into Popular Diets

A “cheat sheet” to help navigate where mushrooms fit into everything from Keto and low FODMAP to Volumetrics and Flexitarian. [download the PDF]

Research

Composition


Composition

U.S. Department of Agriculture, Agricultural Research Service, FoodData Central. https://fdc.nal.usda.gov/.

Phillips KM and Rasor AS. A mixed mushroom control material to facilitate inter-laboratory harmonization of mushroom composition analyses. Journal of Food Composition and Analysis. 48 (2016); 48-66.  https://www.sciencedirect.com/science/article/abs/pii/S0889157516000041 

Bemas E, and Jaworska GY. Vitamins profile as an indicator of the quality of frozen Agaricus bisporus mushrooms. Journal of Food Composition and Analysis. 49 (June 2016); 1-8.

Glamočlija J, Dejan Stojković D, Miloš Nikolić M, Ćirić A, Reis FS, et al. A comparative study on edible Agaricus mushrooms as functional foodsFood Funct. 2015; 6, 1900-1910 doi.10.1039/C4FO01135J.

Muna GA, John M, Benson M, and Ogoyi D. Antioxidant properties of cultivated edible mushroom (Agaricus bisporus) in Kenya. Afr J Biotech 2015. Vol 14, No 16.

Gunawardena D, Bennett L, Shanmugam K, et al. Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-γ activated murine macrophages. Food Chemistry. 2014; 148: 92-96.

O’Neil, Carol et al. Mushroom consumption is associated with increased nutrient intakes and better diet quality in adult participants of the National Health and Nutrition Examination Survey (2001–2010). FASEB J. April 2013. Doi: 10.1096/fj.1530-6860.

Roupas R, Keogh J, Noakes M, Margetts C and Taylor P. The role of edible mushrooms in health: Evaluation of the evidence. Journal of Functional Foods,2012; 4:4. 

Feeney MJ. Mushrooms–intake, composition, and research. Nutr Today 2006;41:219-26.

Dikeman CL, Bauer LL, Flickinger EA and Fahey Jr GC.  Effects of stage of maturity and cooking on the chemical composition of select mushroom varietiesJ Agri Food Chem 2005;1130-8.

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General Health Promotion


General Health Promotion

Ba DM et al. Association of mushroom consumption with all-cause and cause -specific mortality among
American adults: prospective cohort study findings from NHANES III. 
Nutrition Journal
(2021) 20:38. https://doi.org/10/1186/s12937-021-00691-8

Agarwal S, Fulgoni III V, Nutritional
impact of adding a serving of mushrooms to USDA Food Patterns – a dietary modeling
analysis,
 Food & Nutrition Research 2021, 65: 5618 – http://dx.doi.org/10.29219/fnr.v65.5618

Fulgoni VL III, Agarwal S. Nutritional
impact of adding a serving of mushrooms on usual intakes and nutrient adequacy using National Health and Nutrition
Examination Survey 2011–2016 data.
 Food Sci Nutr. 2021;00:1–8. https://doi.org/10.1002/fsn3.2120

Roncero-Ramos & Degado-Andrade. The beneficial role of edible mushrooms in human health. Curr
Opin
 Food Sci 2017. https://doi.org/10.1016/j.cofs.2017.04.002. 
https://www.sciencedirect.com/science/article/abs/pii/S2214799317300632 

Valverde ME, Hernández-Pérez T, and Octavio Paredes-López O. Review article Edible mushrooms: Improving human health and promoting quality
life
International Journal of Microbiology 2015, https://dx.doi.org/10.1155/2015/376387. Open Access.

Feeney MJ, Myrdal-Miller A, and Roupas P. Mushrooms—Biologically distinct and nutritionally uniqueNutr
Today
, Nov. 2014; 49(6): 301-307. Open Access.

Williams B, Marsales H, Millen A, Burton H, Browne R, and Horvath P. Effect of chronic mushroom intake on functional fitness in older men and
women
The FASEB Journal April 2014; 28:1. Supplement 1027.9. 

Feeney MJ, Dwyer J, Hasler-Lewis CM, Milner JA, Noakes M, Rowe S et al. Mushrooms and Health Summit ProceedingsJ.
Nutr.
 144: 1128S–1136S, 2014. 

O’Neill CE, Nicklas TA and Fulgoni III VL. Mushroom intake is associated with better nutrient intake and diet quality: 2001-2010
National Health and Nutrition Examination Survey
Journal of Nutrition and Food
Science
 2013, 3:229. Doi:10.4172/2155-9600.1000229. 

Roupas P, et al The Role of Edible Mushrooms and Health: Evaluation of the
evidence. 
J. Functional Foods, 2010, Vol 4., No. 4, pp 687-709. https://www.sciencedirect.com/science/article/abs/pii/S1756464612000746

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Antioxidants


Antioxidants

Calvo MS et al. A Retrospective Study in Adults with Metabolic Syndrome: Diabetic Risk Factor Response to
Daily Consumption of Agaricus bisporus (White Button Mushrooms)
. Plant Foods Hum Nutr.
 2016 Sep;71(3):245-51.  doi: 10.1007/s11130-016-0552-7. https://pubmed.ncbi.nlm.nih.gov/27193019/ 

Kozarski M, Klaus A, Jakovljevic D, Todorovic N, Vunduk J, Petrovic P, Niksic M, Vrvic MM, and van Griensven
L. Antioxidants of edible mushrooms. Molecules 2015,
20, 19489-19525.

Siu K-C, Chen X, and Wu JY. Constituents actually responsible for the antioxidant activities of crude polysaccharides
isolated from mushrooms.
 Journal of Functional Foods, Vol.11, November 2014,
Pages 548–556.

Martin KR. Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro
binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment.
 Nutr
J
 2010;16:29.

Dubost NJ, et al. Quantification of polyphenols and ergothioneine in cultivated mushrooms and correlation to
total antioxidant capacity
Food Chem 2007;105:727-735.

Dubost NJ, et al. Identification and quantification of ergothioneine in cultivated mushrooms by liquid
chromatography-mass spectroscopy.
 Int J Med Mushr 2006;8:215-22.

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Immunity/Inflammation


Immunity/Inflammation

Calvo MS, Mehrotra A, Beelman RB, Nadkami G, Wang L, Weijing C, Goh Boon C, Kalaras MD and Uribarri J. A retrospective study in adults with metabolic syndrome: Diabetic risk factor response to
daily consumption of Agaricus bisporus (white button mushrooms.
 Plant Foods Hum
Nutr.
 2016 Sept. 71(3):245-51.

Dai X and Percival S. Shiitake-derived beta-glucan, lentinan, reduces CCL3/MIP-1a production via down-modulation
of TLR2-and TLR4-mediated NFkB activation and TLR2 expression in human THP-1 monocytes.
 The
FASEB Journal
 April 2015 Vol. 29, No. 1. Supplement 130.6. 

Dai X et al. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized
Dietary Intervention in Healthy Young Adults
J Am Coll Nutr. 2015 Apr;
11:1-10.

Wang J, Wu D, et.al. Dietary Supplementation with White Button Mushroom Augments the Protective Immune Response
to Salmonella Vaccine in Mice.
 J. Nutr. November 20, 2013. 

Chandra L, et al. White button and shiitake mushrooms reduce the incidence and severity of collagen-induced
arthritis in dilute brown non-agouti mice.
 J Nutr 2011;141:131-6.

Kuvibidila S, Korlagunta K. Extracts from culinary-medicinal mushrooms increase intracellular α-Defensins 1-3
concentration in HL60 cells. 
Int J Med Mushr 2010;12:33-42.

Martin KR. Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro
binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment. 
Nutr
J
 2010;9:29.

Sanhong Y, Weaver V, Martin K, Cantorna MT. The effects of whole mushrooms during inflammation. BMC
Immunol
 2009;10.

Kuvibidila S, Alexander H, Lim YF, Christopher L, Lucas E, Clarke SL, Smith BJ. White button, Shiitake, and Portabella mushrooms modulate the development of
collagen-induced arthritis in mice. 
FASEB J 2009;23.  

Ren Z, Guo Z, Meydani SN, Wu D. White button mushroom enhances maturation of bone marrow-derived dendritic cells and their
antigen presenting function in mice
J Nutr 2008;138:544-550.

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Vitamin D


Vitamin D

U.S. Department of Agriculture, Agricultural Research Service, FoodData Central. https://fdc.nal.usda.gov/ 

Office of Dietary Supplements. Dietary Supplement Fact Sheet: Vitamin D. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/#h3Accessed:
July 2023. 

Cardwell G, Bornman JF, James AP, Black LJ. A
Review of Mushrooms as a Potential Source of Dietary Vitamin
D.
 Nutrients. 2018 Oct 13;10(10):1498. Doi: 10.3390/nu10101498. PMID:
30322118; PMCID: PMC6213178.

Urbain P, and Jakobsen J. Dose−response effect of sunlight on vitamin D2 production in Agaricus bisporus
mushrooms.
 J. Agric. Food Chem., 2015, 63 (37): 8156−8161 DOI.

Chen SY, Yu HT, Kao JP, Yang CC, Chian SS, Mishchuk DO, Mau JL and Slupsky CM. Consumption of vitamin D2 enhanced mushrooms is associated with improved bone
health.
 Journal of Nutritional Biochemistry 2015 Vol. 6 (7):696-703. 

Mehrota A, Calvo, MS, Beelman RB, Levy E, Sluty J, Kalaras MD, and Uribarri J. “Bioavailability of vitamin D2 from enriched mushrooms in prediabetic adults: A randomized
controlled trial.
 European Journal of Clinical Nutrition 2014
Oct;68(10):1154-60 .

Babu, US, Balan KV, Garthoff LH and Calvo MS. Vitamin D2 from UVB-light exposed mushrooms modulates immune response to LPS in
rats.
 Journal of Molecular Nutrition & Food Research. 2014 Issue 2:
318-328.

Phillips, V and Rasor A. A nutritionally meaningful increase in vitamin D in retail mushrooms is attainable by
exposure to sunlight prior to consumption.
 Journal of Nutrition and Food Sciences. 2013;
3:236. Doi:10.4172/2155-9600.1000236. 

Bennett L, Kersaitis C, Macaulay SL, Münch G, Niedermayer G, et al. Vitamin D2-enriched button mushroom (Agaricus bisporus) improves memory in both wild type
and APPswe/PS1dE9 transgenic mice.
 PloS ONE 2013 10): e76362.

Stepian M, O’Mahony L, O’Sullivan A, Collier J, Fraser WD, Gibney MJ, Nugent AP and Brennan L. Effect of supplementation with vitamin D2-enhanced mushrooms on vitamin D status in healthy
adults.
 Journal of Nutritional Science 2013 Vol 23 e29. 

Calvo MS, et al. Vitamin D(2) from light-exposed edible mushrooms is safe, bioavailable and effectively
supports bone growth in rats.
 Osteoporos Int. 2012 Feb 23.

Kristensen HL, Rosenqvist E, Jakobsen J. Increase of vitamin D2 by UV-B exposure during the growth phase of white button mushroom
(Agaricus bisporus).
 Food Nutr Res. 2012; 56.

M.S. Calvo, S.J. Whiting, Survey of current vitamin D food fortification practices in the United States and
Canada
J. Steroid Biochem. Mol. Biol. 2012.

Simon RR, et al. Vitamin D mushrooms: Comparison of the composition of button mushrooms (Agaricus bisporus)
treated post-harvest with UVB light or sunlight.
 J. Agric. Food Chem 2011:
59 (16), 8724–8732.

Phillips KM, et al. Vitamin D and Sterol Composition of 10 Types of Mushrooms from Retail Suppliers in the
United States.
 J Agric Food Chem 2011; 59, 7841–7853.

Koyyalamudi SR, Jeona SC, Song CH, Pang G. Vitamin D2 formation and bioavailability from Agaricus bisporus button mushrooms treated
with ultraviolet irradiation.
 J Agric Food Chem 2009;57:3351-5.

Holick MF, et al. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of
25-hydroxyvitamin D. 
J Clin Endocrinol Metab 2008;93:677-681.  

Feeney M J. Mushrooms–intake, composition, and research. Nutr
Today
 2006;41:219-26.

Dikeman CL, Bauer LL, Flickinger EA, Fahey GC. Effects of stage of maturity and cooking on the chemical composition of select mushroom
varieties.
 J Agric Food Chem 2005;1130-8. 

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Prebiotic/Microbiota


Prebiotic/Microbiota

Tian Y, Nichols RG, Roy P, Gui W, B. Smith PB, Zhang J, Lin Y, Weaver V, Cai J, Patterson AD Cantorna MT, Prebiotic
effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6
mice,
 Journal of Functional Foods, Volume 45, 2018, Pages 223-232, ISSN
1756-4646, https://doi.org/10.1016/j.jff.2018.04.008.

Hess J, Wang Q, Gould T, Slavin J. Impact
of Agaricus bisporus Mushroom Consumption on Gut Health Markers in Healthy
Adults.
 Nutrients. 2018 Oct 2;10(10):1402. doi: 10.3390/nu10101402. PMID:
30279332; PMCID: PMC6213353.

Solano-Aguilar GI, Jang S, Lakshman S, Gupta R, Beshah E, Sikaroodi M, Vinyard B, Molokin A, Gillevet PM, Urban JF
Jr. The
Effect of Dietary Mushroom Agaricus bisporus on Intestinal Microbiota Composition and Host Immunological
Function.
 Nutrients. 2018 Nov 9;10(11):1721. doi: 10.3390/nu10111721. PMID:
30424006; PMCID: PMC6266512.

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Umami, Flavor and Sodium


Umami, Flavor and Sodium

Du X, Sissons J, Shanks M, Plotto A. Aroma
and flavor profile of raw and roasted Agaricus bisporus mushrooms using a panel trained with aroma
chemicals,
 LWT Volume 138, 2021, 110596, ISSN 0023-6438, https://doi.org/10.1016/j.lwt.2020.110596.

Du X, Muniz A, Sissons J, Wang W, Juma S. Consumer
acceptance of egg white partially substituted with mushrooms and mushroom–egg white flavor
pairing.
 Food Sci Nutr. 2021;00:1–12. https://doi.org/10.1002/fsn3.2105

Wong KM, Decker EA, Sutio WR, Toong K, DeStefano G, and Kinchla A. Utilizing mushrooms to reduce overall sodium in taco filling using physical and
sensory evaluation.
 Journal of Food Science. Aug. 2017,DOI:
10.1111/1750-3841.13838.

Summers AC, Adaora D, Smith P, Frutchey R, Lindsey T et al. Acceptance of a mushroom-soy-beef blend burger among school-aged children. May 2017.
Vol. 4, No. 3, 274-281. .https://ingentaconnect.com/contentone/psp/hbpr/2017/00000004/00000003/art00008

Guinard JX et al. Consumer acceptance of dishes in which beef has been partially substituted with mushrooms
and sodium has been reduced.
 Appetite. 2016, Oct. 1;105:449-459.

Summers AC, Smith P, Ezike A, Frutchey R, Fahle J, DeVries E. Taylor J and Cheskin LJ. A pilot study to compare a mushroom-soy-beef burger to an all-beef burger in school
meals.
 The Journal of Child Nutrition and Management, Fall. 2015, Vol 39, Issue
2. 

Myrdal Miller A et al. “Flavor-enhancing properties of mushrooms in meat-based dishes in which sodium has been
reduced and meat has been partially substituted with mushrooms.”
 Journal of Food
Science.
 2014 Sept; 79(9):S1795-804.

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Weight Management


Weight Management

Hess J, Wang Q, Kraft C and Slavin J. Impact of Agaricus bisporus mushroom consumption on satiety and food
intake
Appetite 2017 (Oct). 179-185.

Poddar KH, Cheskin LJ et al. Positive effect of mushrooms substituted for meat on body weight, body composition, and
health parameters. A 1-year randomized clinical trial.
 Appetite 71 (December
2013) 379–387.

Cheskin LJ, et al. Lack of energy compensation over 4 days when white button mushrooms are substituted for
beef.
 Appetite 2008;51: 50-57. 

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Cardiovascular Health


Cardiovascular Health

Uffelman CN, Chan NI, Davis EM, Wang, Y, McGowan BS and Campbell WW. An Assessment of Mushroom Consumption on Cardiometabolic Disease Risk Factors and
Morbidities in Humans: A Systematic Review.
Nutrients 2023, 15, 1079. https://doi.org/10.3390/nu15051079

Lee DH, Yang M, Giovannucci EL, Sun Q, Chavarro JE. Mushroom
consumption, biomarkers, and risk of cardiovascular disease and type 2 diabetes: a prospective cohort study of US
women and men.
 Am J Clin Nutr. 2019 Sep 1;110(3):666-674. Doi:
10.1093/ajcn/nqz057. PMID: 31172167; PMCID: PMC6736198.

Kim SH, Thomas MJ, Wu D, Carman CV, Ordovás JM, Meydani M. Edible
Mushrooms Reduce Atherosclerosis in Ldlr-/- Mice Fed a High-Fat Diet.
 J
Nutr.
 2019 Aug 1;149(8):1377-1384. Doi: 10.1093/jn/nxz075. PMID: 31162580.

Robak TJ, Lalal LA, Morris MJ, Williams BT, Browne RW and Horvath PJ. Acute effects on satiety from white button and shiitake mushroom powder supplementation in
a high fat meal.
 The FASEB Journal April 2016. Vol. 30, No. 1, Supplement
692.20.

Morris MJ, Robak TF, Talal LA, Williams BT, Browne RW and Horvath PJ. Acute effects of white button and shiitake mushroom powder supplementation on postprandial
lipemia following a high fat meal. 
The FASEB Journal April 2016. Vol. 30 No.
1, Supplement 692.27.  

Gil-Ramirez A, et al. Modulation of cholesterol-related gene expression by ergosterol and ergosterol-enriched
extracts obtained from Agaricus bisporus.
 Eur J Nutr. April 2016, Vol. 55
(3): 1041-1057.

Gil-Ramírez A et al. Effect of ergosterol-enriched extracts obtained from Agaricus bisporus on cholesterol
absorption using an in vitro digestion model.
 Journal of Functional Foods, Volume
11, November 2014, Pages 589-597.

Handayani D, Meyer BJ, Chen J, Brown SH, Mitchell TW and Huang XF. A high-dose Shiitake mushroom increases hepatic accumulation of triacylglycerol in rats fed
a high-fat diet: underlying mechanism.
 Nutrients. 2014;6(2):650-662.

Martin KR. The bioactive agent ergothioneine, a key component of dietary mushrooms, inhibits monocyte
binding to endothelial cells characteristic of early cardiovascular disease.
 J Med
Food
 2010;13: 1340-1346.

Petrisko Y, et al. Postprandial serum triglyceride responses following four weeks of consuming two different
very low carbohydrate diets versus a lower fat diet.
 Experimental Biology, San
Francisco, CA. Abstract #109.5 2006.

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Cancer


Cancer

Ba, DM, Sentongo P, Beelman RD, Muscat J, Gao X and Richie Jr JP. Higher Mushroom Consumption is Associated with Lower Risk of Cancer: A Systematic Review
and Meta-Analysis of Observational Studies.
Adv Nutr 2021; 12(5):1691-1704.
Doi:10.1093/advances/nmab015. 

Zhang S, Sugawara Y, Chen S, Beelman RB, Tsuduki T, Tomata Y, Matsuyama S, Tsuji  Mushroom
consumption and incident risk of prostate cancer in Japan: A pooled analysis of the Miyagi Cohort Study and the
Ohsaki Cohort Study.
 Int J Cancer. 2020 May 15;146(10):2712-2720. doi:
10.1002/ijc.32591. Epub 2019 Sep 4. PMID: 31486077; PMCID: PMC7154543.

Lee DH, Yang M, Keum N, Giovannucci EL, Sun Q, Chavarro JE. Mushroom
Consumption and Risk of Total and Site-Specific Cancer in Two Large U.S. Prospective
Cohorts.
 Cancer Prev Res (Phila). 2019 Aug;12(8):517-526. doi:
10.1158/1940-6207.CAPR-19-0101. Epub 2019 Jun 4. PMID: 31164344; PMCID: PMC6677603.

Twardowski P, Kanaya N, Frankel P, Synold T, Ruel C, et al. A phase I trial of mushroom powder in patients with biochemically recurrent prostate
cancer: Roles of cytokines and myeloid-derived suppressor cells for Agaricus bisporus-induced prostate-specific
antigen responses. 
Cancer 2015; May 18. doi. 10.10.1002/cncr.29421.

Li J, Zou L, Chen W, et al.  Dietary mushroom intake may reduce the risk of beast cancer: Evidence from a
meta-analysis of observational studies.
 PLOS One. 2014, DOI:
10.1371/journal.pone.0093437. 

Suzuki N, Yuko T, Riho S, et al. Efficacy of oral administration of Lentinula edodes mycelia extract for breast cancer
patients undergoing postoperative hormone therapy.
 Asian Pacific Journal of Cancer
Prevention.
2013; 14: 3469-3472. doi:10.7314/APJCP.2013.14.6.3469.

Jeong SC, et al. Macrophage immunomodulating and antitumor activities of polysaccharides isolated from
Agaricus bisporus white button mushrooms.
 J Med Food. 2012 Jan; 15(1):58-65

Martin KR, Brophy SK. Commonly consumed and specialty dietary mushrooms reduce cellular proliferation in MCF-7
human breast cancer cells.
 Exp Biol Med 2010;235:1306-14.

Shin A, et al. Dietary mushroom intake and the risk of breast cancer based on hormone receptor
status.
 Nutr Cancer 2010;62:476-83.

Zhang M, Huang J, Xie X, Holman CD. Dietary intakes of mushrooms and green tea combine to reduce the risk of breast cancer in
Chinese women.
 Int J Cancer 2009;124:1404-8.

Hong SA, Kim K, Nam SJ, Kong G, Kim, MK. A case-control study on the dietary intake of mushrooms and breast cancer risk among Korean
wome
n. Int J Cancer 2008;122:919-23.

Adams LS, Phung S, Wu X, Ki L, Chen S. White button mushroom (Agaricus bisporus) exhibits antiproliferative and proapoptotic
properties and inhibits prostate tumor growth in athymic mice.
 Nutr
Cancer
 2008;60:744-56.

Chen S, et al. Anti-aromatase activity of phytochemicals in white button
mushrooms.
 Cancer Res 2006;66:12026-34.

Chen S, et al.Chemopreventive properties of mushrooms against breast cancer and prostate
cancer.
 Int J Med Mushr 2005;7:342-3.

Grube BJ, et al. White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell
proliferation
J Nutr 2001;131:3288-93. 

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Neurocognition


Neurocognition

Solano-Aguilar et al.. The effects of Consuming White Button Mushroom Agaricus bisporus on the Brain and Liver
Metabolome Using a Targeted Metabolomic Analysis
Metabolites 2021, 11,779. https://doi.org/10.3390/metabo11110779

Feng L, Cheah IK, Ngc MM-X, Lic J, Chand SM, Lime SU, Mahendrana R, Heok Kuaa EH and Halliwell B.  The Association between Mushroom Consumption and Mild Cognitive Impairment: A
Community-Based Cross-Sectional Study in Singapore
 Journal of Alzheimer’s
Disease
 68 (2019) 197–203.

Zhang S, Tomata Y, Sugiyama K, Sugawara Y, Tsuji I. Mushroom consumption and incident dementia in elderly Japanese: The Ohsaki Cohort 2006
study
Journal America Geriatrics Society. 2017;65(7):1462Y1469.

Zajac I, Cavuoto P, Danthiir V, Wittert GA, Krause D, Lawson L, Noakes M, Syrette J, Weaver J, Bennett L.  A randomised, double blinded, placebo-controlled clinical trial testing the effects of a
vitamin D-enriched mushroom supplement on cognitive performance and mood in healthy elderly adults: study
protocol
Healthy Aging Research 2016; 5:5.

Thangthaeng N, Miller MG, Gomes SM and Shukitt-Hale B. Daily supplementation with mushroom (Agaricus bisporus) improves
balance and working memory in aged rats
Nutr Res 2015, Dec; 35(12):
1079-84.

Bennett L, Kersaitis C, Macaulay SL, Munch G, Niedermayer G, Nigro J, Payne M, Sheean P. Vallotton P, Dimitrios
Zabaras D, Bird M. Vitamin D2-Enriched Button Mushroom (Agaricus bisporus) Improves
Memory in Both Wild Type and APPswe/PS1dE9 Transgenic Mice.
 PLOS ONE |
www.plosone.org 1 October 2013 | Volume 8 | Issue 10 | e76362.

Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium
erinaceus
) on mild cognitive impairment: a double-blind placebo-controlled clinical
trial.
 Phyther Res. 2009;23(3):367Y372.

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Other Benefits


Other Benefits

Beelman RB et al. Health consequences of improving the content of ergothioneine in the food supply.
F
EBS Letters (2022) doi:10.1002/1873-3468.14268. https://pubmed.ncbi.nlm.nih.gov/34954825/ 

Singdevsachana SK, Auroshree P, Mishrab J, Baliyarsingh B, Tayung K and Thatoi H. Mushroom polysaccharides as potential prebiotics with their antitumor and immunomodulating
properties: A review. 
Bioactive Carbohydrates and Dietary Fibre Vol. 7,
Issue 1, January 2016, pp 1-14. 

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